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doi: 10.1681/asn.2012050536 23 BuoliM.DozioE.CaldiroliL.ArmelloniS.VianelloE.Corsi RomanelliM.et al

Most individuals report better sleep quality within the first week, followed by improved recovery and body composition changes over the following months

The build-up of adenosine and its binding with the adenosine receptor drives us to need to sleep each night, so the interaction with the adenosine receptor theoretically would only increase sleepiness at the end of the day (not making you sleepy during the day)

This study patients received standard clinical management, including dietary protein restriction, specialized medical formula, L-carnitine supplementation, and vitamin B12/hydroxocobalamin therapy, the individual contributions of treatment and disease to the observed metabolic alterations cannot be completely distinguished